Science:
Testosterone, estrogen, thyroid hormone, and DHEA-S act directly in the brain. Their age-related decline is a key, underrecognized driver of cognitive aging.
Action:
Request a comprehensive hormone panel (testosterone, estradiol, DHEA-S, TSH, free T3/T4, IGF-1).
From the Neurologist:
Hormone receptors are dense in the hippocampus and prefrontal cortex. Estrogen supports synaptic plasticity and dendritic spine density; testosterone promotes neurogenesis, myeline integrity, and reduces neuroinflammation; DHEA-S modulates GABA and NMDA signaling. Decline across these systems correlates with hippocampal atrophy and cognitive decline.
References:
Disclaimer: The content published in The Brain Capsule is for informational and educational purposes only. It is not intended to substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider before making any changes to your health, diet, or wellness routine. The views expressed are based on current research and are subject to change as new evidence emerges.